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An experimentally induced mutation in the UBA domain of p62 changes the sensitivity of cisplatin by up-regulating HK2 localisation on the mitochondria and increasing mitophagy in A2780 ovarian cancer cells

Nature 476 , 341345 (2011)

In conclusion, it is not difficult to find that the effect of hypoglycemic drugs on hypoglycemic or renal protection is closely connected with iron metabolism, Nrf2 and lipid metabolism in addition to the classical mechanisms