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HMOX1 knockout mice have anemia and iron accumulation in liver and kidney, which is associated with oxidative damage and tissue injury

Antituberculosis drugs like isoniazid, rifampicin and pyrazinamide have been found to be potentially hepatotoxic [130]

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Behavioral tests, histological staining, oxidative stress markers, and protein expression were examined

Samples were separated by SDS-PAGE (NuPage 412% Bis-Tris Gel, Life Technologies), run with BioRad Precision Plus Protein Kaleidoscope ladder, and transferred to a nitrocellulose membrane using an iBlot system (Life Technologies)