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1 H NMR (600 MHz, CDCl 3 ): 9.20 (s, 1H), 7.54 (d, J = 1.8 Hz, 1H), 7.487.43 (m, 1H), 7.34 (d, J = 8.0 Hz, 1H), 7.12 (ddd, J = 8.2, 7.1, 1.1 Hz, 1H), 7.097.03 (m, 1H), 4.43 (dd, J = 6.7, 4.0 Hz, 1H), 3.73 (s, 3H), 3.38 (dq, J = 11.3, 2.3 Hz, 1H), 3.24 (dt, J = 12.6, 3.1 Hz, 1H), 3.10 (dd, J = 11.2, 5.9 Hz, 1H), 3.052.98 (m, 1H), 2.95 (dd, J = 10.7, 3.0 Hz, 1H), 2.792.73 (m, 1H), 2.67 (td, J = 11.2, 4.4 Hz, 1H), 2.432.35 (m, 1H), 2.22 (t, J = 11.0 Hz, 1H), 2.162.09 (m, 1H), 1.28 (q, J = 11.8 Hz, 1H), 1.18 (d, J = 6.6 Hz, 3H)

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44 In subsequent studies, transgenic mice expressing constitutively active MLCK (CA-MLCK), specifically within the intestinal epithelial cells, demonstrated significant gut permeability in the jejunum (using bovine serum albumin) and the colon (using creatinine and sucralose)

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Gromadziska, J