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10.1038/s41598-022-18872-8 58 NagaiM.VoN

[DOI] [PubMed] [Google Scholar] 76.Rinella M.E., Sanyal A

Direct Evidence from Brain Tissues Researchers have found significantly reduced activity of complexes I and V and mitochondrial enzyme pyruvate dehydrogenase in various regions of the brain [67]

The duration of the therapeutic effect is dictated by the residency time of the drug within the lung/receptor site, which can be manipulated by changing the chemical properties of the drugs delivered via inhaled delivery devices (Labiris and Dolovich 2003)