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Peter Illes, Leipzig University, Germany Updates Copyright 2021 Bustamante-Barrientos, Mndez-Ruette, Ortloff, Luz-Crawford, Rivera, Figueroa, Molina and Btiz

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33 This process is further enhanced by SQSTM1 that increases NFE2L2 protein stability through the inactivation of kelch-like ECH-associated protein 1 (KEAP1), an adapter protein of the Cullin3-based ubiquitin E3 ligase complex responsible for NFE2L2 ubiquitination

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Funding The work was financially supported by the National Natural Science Foundation of China (contract no

Folate, vitamin B6, and vitamin B12 deficiencies are due to poor dietary intakes, illness, genetic defects that result in impaired absorption or transport, or a combination of these factors.9 Although clinical deficiencies of these vitamins are uncommon in the United States and are usually limited to individuals with genetic mutations, low or marginal deficiencies have been reported, particularly among nonwhite and elderly populations, and women of childbearing age