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N.OsipovaV

Atovaquone used alone can cause drug resistance but evidence that clindamycin and atovaquone with azithromycin can effectively treat Babesia has previously been reported in both animals [171], and humans [172], although there is now greater recognition of resistance to standard Babesia regimens [153,163], especially in immunocompromised patients with babesiosis when 6 weeks of therapy or longer may be necessary [172]

10.1016/j.bbrc.2018.10.185 517 YangS.-H.LiuR

Excessive alcohol intake has been demonstrated to increase PARP1 activity, resulting in a reduction of hepatic NAD + and SIRT1 activity (Huang et al