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10.1038/s41467-018-05944-5 232 RossnerP.OrhanH.KoppenG.SakaiK.SantellaR

Cancer Cell 19 , 125137 (2011)

When protein synthesis was blocked by CHX, sparing of cysteine from protein translation was sufficient to reactivate mTORC1 and relieve the ISR (Fig

However, peptide therapy offers the advantage of extended treatment duration (daily dosing over weeks) versus the single or limited injection approach of PRP