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The mechanisms underlying these improvements are well-documented, and the clinical evidence supporting them is stronger than what exists for many mainstream skincare ingredients

NMDA receptors, when overactive, contribute to excitotoxicity and excessive neural firing

Inhibition of SIRT1 promotes inflammatory reactions since SIRT1 inhibits transcription of nuclear factor kappa B (NF-B) which also inhibits SIRT1 activation via activation of microRNA and miR-34a which reduce NAD synthesis

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