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Transdermal gels and creams (both FDA-approved and compounded), vaginal preparations for genitourinary symptoms, sublingual troches, and injectable estradiol are all available

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Metabolic approaches: GLP-1 Incretins (semaglutide): appetite suppression | GLP-1/GIP incretins (tirzepatide): dual hormonal agonism | 5-Amino-1MQ: NNMT enzyme inhibition a non-hormonal mechanism, directly targeting lipid and NAD+ metabolism

We observed CaOx crystal deposition, tubular dilatation, inflammatory cell infiltration, and apoptosis in the Gly group

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This was demonstrated using Nrf2/ mice and N-acetylcysteine administration prevented these changes (Thimmulappa et al., 2006)