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Role of glutathione metabolism in host defense against Borrelia burgdorferi infection

The electrical shock of an ICD/CRT-D can cause an increase in ROS/RNS concentration, but it can also be its result

Andreeff M , Tafuri A, Bettelheim P, Valent P, Estey E, Lemoli R, Homge M, Collins D, Goodacre A, Clarkson B, Mandelli F, Deisseroth A

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Alternatively, the up-regulation of ddh may be due to direct inhibition of the enzyme by DSF and/or DDTC

Whether partial TCA cycle reverse activity due to the large accumulation of fumarate, leading to SDH reversal and fumarate reduction to succinate, as it has been observed in ischaemia [36], or cells treated with mitochondrial inhibitors [37], occurs in Fh -1 deficient cells has not been reported