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If you have slow COMT, you might want to avoid high-dose copper supplements or multis with copper unless a deficiency is confirmed, because copper can increase neurotransmitter production

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Zhang, X.-D

Philadelphia (PA): Saul Ewing LLP

Iio A, Ohguchi K, Maruyama H, Tazawa S, Araki Y, Ichihara K, Nozawa Y, Ito M (2012) Ethanolic extracts of Brazilian red propolis increase ABCA1 expression and promote cholesterol efflux from THP-1 macrophages

Lafferty, E