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The BBB is mainly composed of vascular endothelial cells (ECs) and basement membrane (BM), and there are also pericytes and astrocyte end-feet covering them, which together constitute the neurovascular unit (NVU) to maintain the function of BBB (Yao et al., 2014

Several GLS inhibitors such as compound 968, BPTES, and CB-839 are currently in preclinical studies [19, 61]

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Notably, polyunsaturated fatty acids (PUFAs), folates and probiotics have shown positive effects on these aspects (Table 2)