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However, long-term NNMT inhibition in humans hasn't been characterized beyond small pilot cohorts, so concerns about sustained NAD+ elevation (which could theoretically promote certain cancers via PARP or SIRT activation) remain speculative but unresolved

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Present Knowledge in Nutrition

Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: role of interleukin-6 and disease duration