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Supplementation with 300-600 mg/day has been shown to increase intracellular glutathione levels by 30-70% in cell culture and animal studies, with more modest increases in human trials (Suh et al., Proc Natl Acad Sci, 2004) [25]

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The recovery phase varies from hours to days, and patients are slowly able to resume oral intake and return to baseline

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This temporal regulation of autophagy genes promotes A degradation through the activation of astrocytic autophagy, whereas the pharmacological inhibition of autophagy exacerbates mitochondrial dysfunction and oxidative stress, ultimately leading to astrocyte death

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