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Description

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

Adv Pediatr Infect Dis 36:247276 Almeida CB, Scheiermann C, Jang JE, Prophete C, Costa FF, Conran N, Frenette PS (2012) Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice

213:W218-W227

These inhibitors are being investigated as potential therapeutic agents for various diseases, including cancer, Alzheimers disease, and type 2 diabetes [262]

Acetylation modification of the BIM gene expression Forkhead box O3a (FoxO3a) is an important transcription factor belonging to the FoxO family, and is widely involved in various biological processes such as cell growth, metabolism, apoptosis, and stress responses