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Questa funzione antiossidante contribuisce al benessere generale di vari tessuti e organi, tra cui cuore, cervello e muscoli scheletrici

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J Neurosci Res 97:8897

Endothelin-1 (ET-1) synthesized by vascular endothelial cells is a potent vasoconstrictor and acts through two receptors: ET A and ET B

M2 macrophages, as infiltration-rich immunosuppressive cells, are able to activate the PI3K/AKT/mTOR signaling axis by secreting IGF-1 and IGF-2, which promotes thyroid cancer cell invasion and the expression of stemness markers (Oct4, SOX2 and CD133), exacerbating the immunosuppressive effects of cancer (74)