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387 All the above findings underscore the importance of the microbiota in immunotherapy outcomes and support the potential of manipulating microbial communities to increase therapeutic efficacy

65,76 In 2012, Pillay et al

High creatinine refers to the condition where serum creatinine levels exceed the ideal range

Long-term oral administration of an HNF4 agonist prevents weight gain and hepatic steatosis by promoting increased mitochondrial mass and function

Further, a secondary analysis of a trial in women at high risk for or with existing cardiovascular disease reported that high-dose supplemental B-vitamins (1 mg/day of vitamin B 12 , 50 mg/day of vitamin B6, and 2.5 mg/day of folic acid) for 7.3 years had no effect on risk of non-vertebral fractures (122)

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