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449 Modern pharmacological studies have further demonstrated that rhubarb can inhibit the MAPK signaling pathway, thereby alleviating AP-related pathological damage

Wang M , Ramchandren R, Chen R, Karlin L, Chong G, Jurczak W, Wu KL, Bishton M, Collins GP, Eliadis P, Peyrade F, Lee Y, Eckert K, Neuenburg JK, Tam CS Concurrent ibrutinib plus venetoclax in relapsed/refractory mantle cell lymphoma: the safety run-in of the phase 3 SYMPATICO study

Chronic insomnia often involves multiple dysfunctions within sleep-wake pathways, neurotransmitter circuits, glial regulation, and circadian rhythm coordination

Instead, therapeutic efficacy increasingly depends on integrated protocols, monitored through biomarkers that reflect dynamic changes across molecular, cellular, and network levels

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