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These include inhibiting DNA binding activity of EBNA1 (351, 352), disrupting homodimerization (353), blocking its interaction with key host cellular proteins, such as USP7, CK2 or targeting its oncogenic partners, such as MDM2 (354)

Case Rep Neurol Med 2013

Clinical trials have shown that topical application can improve skin density, reduce fine lines, enhance clarity, and increase overall skin thickness

Microglial ferroptosis can activate neurotoxic astrocytes through pro-inflammatory signaling, and ferroptosis-related genes such as ALOX5/15 are highly enriched in microglia, yet this study does not establish whether ferroptosis is upstream in the cascade involving mitochondrial complex IV defects, oxidative stress, and neuroinflammation

Finally, our results demonstrate that androgen signaling serves as a potent stimulating signal driving HHEX expression in the adrenal at puberty, but other hormonal factors, such as estrogens, might also influence adrenal functions and were not addressed in the current study

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