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Studies show that tirzepatide elicits a cyclic AMP response in human beta cells significantly higher than what either GIP or GLP-1 produces alone

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Specifically, it was shown to potently stimulate insulin release in response to glucose, and to restrict glycemic excursion, beyond that of the GLP-1 albumin fusion composed of WT albumin, likely due to a higher concentration in plasma

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The vitamin deficiency concern arises from how GLP-1 receptor agonists alter gastric physiology

It also plays a role in detoxification by conjugating with toxins to facilitate their excretion