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Decitabine, an analog of 5-azacytidine, is also a potent DNMT1 inhibitor with a more favorable safety profile but decitabine is rapidly deaminated and inactivated by cytosine deaminase, if taken orally

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Due to the modifications to 425.512(a)(2)(iii) above, we are also finalizing to add a new paragraph (iv) at 425.512(a)(2) to establish that, for performance years 2027 and subsequent performance years, an ACO in the first performance year of the ACO's first agreement period under the Shared Savings Program will meet the quality performance standard if the ACO reports the APP Plus quality measure set and meets the data completeness requirement on all eCQMs/Medicare CQMs, and the CAHPS for MIPS survey (except as specified in 414.1380(b)(1)(vii)(B)), and receives a MIPS Quality performance category score for the applicable performance year

Although these therapeutic strategies hold potential, their effectiveness in different liver disease contexts still requires substantial evidence

Healthcare providers carefully monitor patients' progress throughout the treatment period, adjusting protocols as needed for optimal results

doi: 10.1186/s13148-019-0741-y