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Furthermore, its potential in treating various diseases, particularly neurodegenerative and respiratory diseases, requires further investigation

Finally, they reflect pathways likely additional to those involved in the angiogenesis (Vukojevic et al., 2018), recently associated in particular with the increased expression, internalization of VEGFR2, and the activation of the VEGFR2-Akt-eNOS signaling pathway (Hsieh et al., 2017) (see Genes Expression as Support ), given the rapid presentation of all of these effects, which occurred before the process of angiogenesis could be initiated (Sikiric et al., 1993

Using high-throughput screening, we subsequently identify AG1, a small molecule that increases the activity of the wild-type, the Canton mutant and several other common G6PD mutants

These processes express the P2RY12 receptor and make direct contact with smooth muscle cells, pericytes, and endothelial cells of the vasculature (Csszr et al., 2022)

[PubMed: 22085343] 733

The information on medication with potential effects on different metabolic pathways is summarized in Table 2