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In vitro studies showed that AS-IV (10, 20, 40 M, pretreated for 2 h) significantly protected against MPP + -induced astrocyte apoptosis without significant cytotoxicity

Pore-forming mediators such as gasdermins and NINJ1 were also not involved

pilosa aqueous extracts was found to be mildly toxic in acute and subchronic toxicity tests but caused no damage to vital organs, with an LD 50 greater than 5,000 mg/kg in rats (663)

Samples were reverse-transcribed using ProSTAR (Stratagene, La Jolla, CA, USA)

(2022) 'Randomized clinical trial of long-term glutathione supplementation in type 2 diabetes', Antioxidants , 11(5), 1026

ROS build up in stressed mitochondria has been proposed as a major player at the origin of NIHL (Bttger and Schacht, Figure 2)