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[DOI] [PubMed] [Google Scholar] 59.Haraldsdottir S., Hampel H., Tomsic J., Frankel W.L., Pearlman R., de la Chapelle A., Pritchard C.C

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Various pharmaceuticals taken by mothers during pregnancy are implicated in the etiology of ASD and detailed in systematic reviews and meta-analyses include: antibiotics based on twelve studies (6,264,831 patients), when taken in all trimesters [335]

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These differences could be only captured using morphometric digital analysis of NASH and fibrosis features

Nrf2 is a key regulator, promoting HO-1 expression by activating the oxidative stress response ( BTB and CNC homology 1 (BACH1) suppresses HO-1 transcription under normal conditions, and stress signals lead to its degradation, allowing Nrf2 to initiate HO-1 expression ( activator protein 1 (AP-1) , heat shock factor 1 (HSF1) , nuclear factor kappa B (NF-B) , and hypoxia-inducible factor 1 alpha (HIF-1) contribute to the activation of HO-1 under various stress conditions ( In conclusion, the dual role of HO-1 is determined by a complex network of regulatory factors