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One compound reduces energy intake, the other increases energy expenditure at the mitochondrial level

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16 The results suggest that B12 can improve brain function in those showing signs of decline, particularly when active forms are supplemented

Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities

2.1 Literature search A systematic search of the PubMed, EMBASE, Cochrane Library, Web of Science, and CNKI databases for relevant observational studies published until 15 March, 2022, was undertaken independently by two reviewers (Zhao and Li)

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