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FIGURE 2 Epigenetic modifications in key genes related to stress and immunity, such as nuclear receptor subfamily three group C member 1 (NR3C1), TNF, and nuclear factor kappa B (NF-B), modulate both the negative feedback of the HPA axis and inflammatory pathways mediated by NF-B, suggesting a link between endocrine dysregulation and immune activation (Palma-Gudiel et al., 2021)

Nrf2is a key factor in the control of the expression of genes involved in the regulation of oxidative stress, via the enhanced production of cellular antioxidants

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At the 3 end of the gene, alternative splicing gives rise to at least three subsets of RNA transcripts, each encoding three distinct carboxy-terminal portions of the unique E-domain extension-peptide (E-peptide) as well as the 3-untranslated region (3UTR) (17,25,3136)

Glucose Homeostasis: Studying the modulation of insulin sensitivity and carbohydrate metabolism

doi: 10.1016/j.arr.2023.102077 64