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Vitamin C Fascinated with the multifaceted role of vitamin C (ascorbic acid) in maintaining health, he began combing the scientific and medical literature for experimental and clinical evidence as to its importance

This view was further supported by the impaired suppression of the -H2AX foci in the DsupC-expressing cells (Supplementary Fig

Combined treatment reduced tumor burden in vivo , suggesting HMGB1-mediated ferroptosis sensitizes tumors to NK clearance ( 4 -treated cells, marked by reduced SLC7A11, GPX4, ferritin, and increased MDA, CD71, transferrin, and HMGB1

Using high-content imaging-based BAC-GFP reporters, it was shown that AQ-QI and DEAQ-QI specifically activated the endoplasmic reticulum (ER) stress response

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A groundbreaking approach introduced by Guo, Boda et al., outlines a novel cancer therapy tactic that involves the creation of a ROS-sensitive polymer, PHPM, which is utilized to concurrently encapsulate elesclomol and copper into nanoparticles, dubbed NP@ESCu