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The redox activity of hemoglobins: from physiologic functions to pathologic mechanisms

Specifically, as proposed in a hypothetical model shown in Figure 7(b), if a protein or a small molecule target could be designed under diabetic conditions to reduce metabolic pressure on complex I, that is, relaying excess electrons from NADH to CoQ, such a target could serve as a potential therapeutic approach by restoring NADH/NAD + redox balance in the absence of enhanced proton pumping and ROS production

Clarke C, Gallagher C, Kelly RM, Henry M, Meleady P, Frye CC, Osborne MD, Brady CP, Barron N, Clynes M (2019) Transcriptomic analysis of IgG4 Fc-fusion protein degradation in a panel of clonally-derived CHO cell lines using RNASeq

Funding This project was supported by the National Key R&D Program of China (Grant No

discovered that radiation-resistant PCa cells and PCa stem cells (CSCs) have high Gln requirements (94)

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