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The goal is not just closure

Segel, I.H

Chabory E, Damon C, Lenoir A, et al

Although it does not affect physical health, it can disrupt periorbital esthetics, revealing a tired and aged appearance, thereby affecting the patients quality of life (Citation13)

196,283,284,285,286,287,288,289 Case reports from Italy have shown that patients with a history of psoriasis and previous treatment with IL-17A antagonists including secukinumab and ixekizumab showed relatively mild COVID-19 symptoms or were even asymptomatic

300,301 Recent findings suggest that exposure to certain environmental factors such as pesticides can augment astrocyte proinflammatory signalling and thereby promote CNS autoimmune inflammation