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Many studies have used the urinary ratio of lactulose to mannitol (LMR) in order to correct for differences in absorption kinetics through gastrointestinal motility and alterations in renal excretion

DAQ conjugates with GSH to form GSHDAQ

Clinically, anti-angiogenic agents can reverse these immunosuppressive circuits by normalizing tumor vasculature (improving T-cell infiltration) and reprogramming myeloid cell populations (83)

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For example, triphenylphosphonium cation and ischemic myocardium-targeting peptide-modified liposomes (PUE@T/I-L) were designed to target mitochondria, increasing puerarin localization in the myocardium, reducing oxidative stress, protecting myocardial cells from ischemia-reperfusion injury, and decreasing infarct size (Wang et al., 2024a)