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The team tested the induction of antibody response by the GPI-RBD-GM-CSF fusion protein by immunizing BALB/c mice with either the fusion protein or VLPs incorporated into the fusion protein along with GPI-IL-12

Nance KD, Gamage ST, Alam MM, Yang A, Levy MJ, Link CN, et al

Beyond cellular constituents, BMAC contains a rich array of bioactive factors such as platelet-derived growth factor (PDGF), TGF-, vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), insulin-like growth factor I (IGF-I), granulocyte-macrophage colony-stimulating factor (GM-CSF), bone morphogenetic proteins (BMP-2/7), and interleukins (IL-1, IL-6, IL-8) [33,34,35]

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This is important because, many times, a diagnosis may be delayed because other conditions, such as irritable bowel syndrome, lactose intolerance or hemorrhoids, are mistakenly considered instead