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Mammalian erythrocytes on the other hand modulate the innate immune response through generation of reactive oxygen species (ROS) to promote inflammatory and autoimmune response against invading microorganisms [108]

Zhang et al., 2021b) (Figure 4)

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Clinical monitoring and patient safety advice includes: Gastrointestinal symptoms : Patients should report severe or persistent nausea, vomiting, or abdominal pain, which may indicate pancreatitis (a warning in tirzepatide labeling) or require dose adjustment