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Simple (1:1) randomization was performed using a randomization website by the blinded clinical research coordinator

[DOI] [PubMed] [Google Scholar] Piotrovskij VK, Kallay Z, Gajdos M, Gerykova M, Trnovec T

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

Representative strategies targeting this axis, from glycolytic enzyme inhibitors to lactylation modulators, have advanced from preclinical validation to early-phase clinical trials, with select agents demonstrated preliminary safety and target engagement

Blocking GSDME-mediated pyroptosis in renal tubular epithelial cells alleviates disease activity in lupus mice

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