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While certain senolytic compounds have shown specificity for senescent cells in preclinical models, achieving this selectivity in humans remains a significant hurdle.120 For example, some senescence-associated proteins (eg, BCL-2, p53, SASP factors) are also expressed in normal, proliferating cells, leading to potential off-target effects.31 Therefore, optimizing senolytic agents to minimize side effects while maintaining efficacy is crucial

Recovery claims are only useful when outcomes are measurable

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Results: Median age of the whole sample was 56 years (49-63)

Given the investigational nature of these compounds, most PK data is derived from animal models

Clem, R