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On the contrary, TRIM14 and TRIM59 have been shown to prevent the ubiquitination and subsequent p62-mediated autophagic degradation of the DNA sensing enzyme cGAS (Tan P

Insulin resistance in adipose tissue, which is often related to obesity, compromises the inhibitory effects of insulin on adipose tissue lipolysis, leading to increased free fatty acids (FFAs) in portal circulation 4,5,6