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Rationale and design of a randomised phase III registration trial investigating finerenone in participants with type 1 diabetes and chronic kidney disease: the FINE-ONE trial

Verwendungshinweise Eine optimale Nahrungsergnzung wird erzielt, wenn tglich 2 Tabletten vor einer Mahlzeit mit ausreichend Wasser verzehrt werden

10.1006/nbdi.2001.0430 121 LinC

Y.PasschierJ.KoesB

doi: 10.1186/s12935-025-03681-6, 28 DanielsB

(2) Dual blockade of the NF-B/AP-1 signaling axis via inhibition of IKK phosphorylation (IC50 = 5.8 M) to reduce NF-B nuclear translocation, coupled with suppression of JNK/ERK phosphorylation (EC50 = 7.2 M) to impede c-Jun/Fos complex formation, thereby synergistically downregulating MMP-1/3/9 transcription (Hwang et al., 2013