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, 200 , 115392, Baldus, S., Eiserich, J

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Additionally, mitochondria are able to activate different intracellular signaling pathways necessary to defend the host against pathogens such as the mitochondrial anti-viral signaling (MAVS) and activation of the nucleotide-binding oligomerization domain (NOD)-, leucine-rich repeat (LRR)- and pyrin domain-containing protein 3 (NLRP3) inflammasome by mitochondrial DNA (mtDNA) (Zhong et al., 2018)

It enhances bioavailability by employing mitochondrial approaches such as triphenylphosphonium (TPP) modification, consequently amplifying its antioxidant and anti-apoptotic properties (160, 161)

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