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"Early exposure to tobacco during pregnancy apparently affects the individuals response to cigarettes in later adolescence and adulthood." The researchers statistical analyses indicated that the associations between maternal smoking during pregnancy and offsprings future smoking were independent of socioeconomic status, maternal age at pregnancy, offspring sex, and offspring age at the time of the interview

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56 SPDEF controls goblet cell transcriptional programs, including forkhead box A3 (Foxa3), and together these two transcription factors regulate goblet cell differentiation and mucus production