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The cellular interactions in chicken testes were three times greater than those in human testes, mainly involving TGF- signaling, VEGF signaling, BMP signaling, FGF signaling and activin signaling

This can complicate clinical trials by making it difficult to attribute outcomes to the new agent, potentially affecting efficacy assessments and regulatory approval (Theuretzbacher and Piddock, 2019)

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Doll et al

doi: 10.1016/j.jep.2021.114647 89

In the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC Study) [89], a treatment strategy comprising pravastatin, vitamin E and decreasing homocysteine in order to combat oxidative stress resulted in a significant decline in common carotid intima-media thickness and an improvement in brachial artery flow-mediated dilatation and urinary albumin excretion