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Singly-housing animals, which prevents inter-animal coprophagy, reduces beta diversity of the microbiome compared to stressful (chronic subordinate colony) co-housing conditions 72

It inhibits NNMT (nicotinamide N-methyltransferase), an enzyme regulating metabolism, fat storage, and NAD+ consumption.[4][27][6] NNMT methylates nicotinamide, a NAD+ breakdown product, diverting it from recycling and reducing available NAD+

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