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These drugs, like semaglutide and tirzepatide, have been rigorously tested over years of clinical human trials and have been FDA approved to treat obesity

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Pharmacokinetics: Cyt-P450 induction by these two drugs also enhances the metabolism of a wide variety of drugs including warfarin, oral contraceptives & metoprolol (amongst others)

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NAD + depletion elevates the methylation of BDNF promoter, triggering the dissociation of the DNA methylation-sensitive nuclear factor CCCTC-binding factor (CTCF) and cohesin from the BDNF locus