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2-DG, a non-metabolizable glucose analogue, is one of the most frequently used antiglycolytic agents and it has come under increasing scrutiny as a therapeutic agent, especially in cancer 24

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Doses up to 60mg/kg per day produced no observable toxicity

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In vitro , MNA has shown significant effects in increasing energy expenditure and modulating glucose metabolism [11, 14], but in vivo , its effects are controversial