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3.2 MAPKAPK2 overexpression mitigates H2O2-triggered cellular toxicity as well as restores melanogenic capacity within melanocytes affected by vitiligo To evaluate the cytoprotective function of MAPKAPK2 under oxidative insult conditions, PIG3V cells were exposed to H 2 O 2 and transfected with either an empty vector or MAPKAPK2-expressing plasmid

MMP9 inhibition prevented NF-KB activation and restored PVIN/PNN integrity, linking redox-controlled MMP9 to excitatory/inhibitory imbalance ( In the brain, the major regulator of redox status is GSH, which has also been shown to regulate inflammation

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PubMed Central , Laboratory Medicine , vol