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It has been suggested that due to the upregulation of K ir 4.1, T-type voltage-sensitive Ca 2+ channels (T-VSCCs) in neurons are activated and initiate NMDAR-dependent neuronal bursts, causing the LHb to trigger depression (Zhao et al., 2022)

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Besides controlling fruit ripening or flower senescence, ACO s have also been targeted in other ethylene-related processes

J Invasive Cardiol 14(6):347-52, 2002

Through mechanisms that are not entirely defined, growth factor signaling activates mTORC2, and upon its activation, mTORC2 phosphorylates and activates Akt and other members of the AGC kinase family (Zhao et al., 2007)