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Geneva, Switzerland: 2001

In another randomized, double-blind, placebo-controlled trial, twice-daily supplementation with 250 mg of magnesium oxide plus 220 mg of zinc sulfate (equivalent to 50 mg elemental zinc) for 12 weeks significantly reduced serum hs-CRP and protein carbonyl (PCO) levels and markedly elevated plasma TAC compared with the placebo (106)

VEGFA: vascular endothelial growth factor A

These technologies reveal the dynamic astrocyte-neuron lactate shuttle: during learning/memory, astrocytic glycogen-derived lactate transported via MCTs promotes Arc/cAMP response element-binding protein (CREB)-dependent synaptic plasticity

This is linked to a combination of factors such as reduced intestinal motility, lower gastric acid output, and diminished BAs secretion, all of which lead to delayed clearance of intestinal contents [43, 44]

The widely accepted hypothesis proposes that motor neuron degeneration arises from the interaction between genetic susceptibility and environmental factors, primarily through mitochondrial dysfunction and cytoskeletal disruption mediated by oxidative stress and excitotoxicity (Zhou et al., 2023)