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During auto-oxidation, excess glucose binds (protein glycation) [37] to lysine and valine residues in tissue and plasma proteins

The initiating factor of ALS is hypothesized to be a combination of multigenic and environmental factors [7] acting as multiple hits toward a threshold at which genetic and epigenetic changes converge into a pathologic cycle of degeneration

Dr Stern is the senior author

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[DOI] [PubMed] Buie T, Campbell DB, Fuchs GJ, Furuta GT, Levy J, Vandewater J, Whitaker AH, Atkins D, Bauman ML, Beaudet AL, Carr EG, Gershon MD, Hyman SL, Jirapinyo P, Jyonouchi H, Kooros K, Kushak R, Levitt P, Levy SE, Lewis JD, Murray KF, Natowicz MR, Sabra A, Wershil BK, Weston SC, Zeltzer L, Winter H

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