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At the same time, extracellular matrix glycosaminoglycans (GAGs) were exposed to the intestinal microflora, released GAG-degrading enzymes comprised of chondroitinase, hyaluronidase, and tryptophanase, the productions of which could conversely exert a cytotoxic effect on IECs [38, 39]

In addition, the tyrosine kinase Src can directly phosphorylate G6PDH and induce its translocation 20

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Contact Information Takyiah Stevenson, PharmD Center for Drug Evaluation and Research Food and Drug Administration 10903 New Hampshire Avenue WO31-2417 Silver Spring, MD 20993-0002 Phone: 240-402-2507 Email: [email protected] FDA Advisory Committee Information Line: 301-796-8220 Please call the Information Line for up-to-date information on this meeting