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Similarly, mice exposed to CUMS for 6 weeks showed an increased interferon-gamma (IFN-) and decreased anti-inflammatory IL-10 levels, demonstrating anti-inflammatory suppression with further pro-inflammatory activation (Jia et al., 2024)

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Other studies have confirmed statin can activate NOS gene transcription, extend the half-life of NOS mRNA in skin cells and inhibit mevalonate- mediated isoprenoid synthesis to increase endothelial NOS activity [43] ( Figure 4 )