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Also, through the technique of titration, the intravenous route provides an avenue for the controlled administration of drugs that have a very narrow margin of safety between therapeutic and toxic concentrations

Notably, the positioning of the pHAT domains influences the wider active site environment via key conformational changes in the flexible arm region

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That process concentrates the platelets in plasma

High methylation of upstream genes of ER suppresses ER expression, thereby promoting tamoxifen resistance, such as p21, WT1, and miR-27b