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Emerging therapies, such as TYK2 inhibitors, RORt inhibitors, and novel PDE4 inhibitors, aim to improve treatment efficacy while minimizing adverse effects

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Research has demonstrated that neuronal activity and functional connectivity are suppressed in the nucleus accumbens (a subregion of the ventral striatum) and ventrolateral periaqueductal gray (Guo et al., 2022)

Appl Environ Microbiol 76:64706476 Laurent V, Loisel TP, Harbeck B, Wehman A, Grbe L, Jockusch BM, Wehland J, Gertler FB, Carlier M-F (1999) Role of proteins of the ena/vasp family in actin-based motility of Listeria monocytogenes

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